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Solid State Lasers and Laser Diodes from RPMC Lasers Inc » Products » DNA Sequencing Lasers

DNA Sequencing Lasers

DNA sequencing is an extremely powerful tool that allows the identification of the four basic DNA molecules adenine (A), cytosine (C), guanine (G), and thymine (T) by tagging them with fluorescence reporter molecules.  This allows for the rapid determination of the precise order of A, C, G, and T molecules allowing for the entire DNA strand to be coded.  In DNA sequencing lasers are focused either through a flow channel (like in flow cytometry) or onto a microplate where the tagged molecules ordered and scanned.  Like all fluorescence applications, most of the visible wavelengths can be used in DNA sequencing, but it’s essential that all DNA sequencing lasers have a high quality TEM00 beam profile.  On this page, you will find a list of all of the full range of DNA sequencing lasers we offer at RPMC, including our multi-laser combiner.

RPMC has years of experience supporting DNA sequencing applications, helping industry professionals select the right tool for the job.


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In conclusion, if you have any questions or would like some assistance please contact us here. Furthermore, you can email us at info@rpmclasers.com to talk to a knowledgeable Product Manager. Alternatively, use the filters on this page to assist in narrowing down the selection of DNA sequencing lasers for sale. Finally, head to our Knowledge Center with our Lasers 101 page and Blogs, Whitepapers, and FAQ pages for further, in-depth reading.

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Picture Part Number Type Output power (W) Mode Output Linewidth Pulse energy (uJ) Rep rate
1030L-1XB: 1030nm Laser (DPSS; MATCHBOX 2) 1030L-1XB CW DPSS Lasers 0.300, 0.400, 0.500 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port
1123L-1XB: 1123nm Laser (DPSS; MATCHBOX 2) 1123L-1XB CW DPSS Lasers 0.100, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
1319L-1XB: 1319nm Laser (DPSS; MATCHBOX 2) 1319L-1XB CW DPSS Lasers 0.100, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
1550L-1XA LD Module 0.080, 0.120 Single-Mode Lasers Free Space, SM Fiber, PM Fiber
405L-1XA: 405nm Laser (Diode; MATCHBOX 2) 405L-1XA LD Module 0.100, 0.150, 0.180 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
450L-3XA: 450nm Laser (HP MM Diode; MATCHBOX 2) 450L-1XA LD Module 0.035, 0.050, 0.060 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
488L-1XA: 488nm Laser (Diode; MATCHBOX 2) 488L-1XA LD Module 0.020, 0.030, 0.040 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
IO Matchbox 505nm Laser 505L-1XA LD Module 0.060 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
515L-1XA LD Module 0.010, 0.020, 0.025 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
520L-1XA: 520nm Laser (Diode; MATCHBOX 2) 520L-1XA LD Module 0.040, 0.070, 0.080 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
532L-1XB: 532nm Laser (DPSS; MATCHBOX 2) 532L-1XB CW DPSS Lasers 0.100, 0.150, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port
532L-2XB: 532nm Laser (SLM DPSS; MATCHBOX 2) 532L-2XB CW DPSS Lasers 0.025, 0.040, 0.050 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
532L-3XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-3XB CW DPSS Lasers 0.400, 0.500 Multimode Free Space, MM Fiber, SMA Port
532L-4XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-4XB CW DPSS Lasers 0.050, 0.080, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
532L-4XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-6XB CW DPSS Lasers 0.050, 0.080, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
638L-1XA: 638nm Laser (Diode; MATCHBOX 2) 638L-1XA LD Module 0.060, 0.080, 0.100, 0.120, 0.170, 0.500, 0.600 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
638L-1XA: 638nm Laser (Diode; MATCHBOX 2) 638L-3XA LD Module 0.500, 0.600 Multimode Free Space, MM Fiber
660L-1XA: 660nm Laser (Diode; MATCHBOX 2) 660L-1XA LD Module 0.060, 0.080, 0.090, 0.110 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
785L-1XA: 785nm Laser (Diode; MATCHBOX 2) 785L-1XA LD Module 0.120, 0.150, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
785L-3XA: 785nm Laser (HP Diode; MATCHBOX 2) 785L-3XA LD Module 1.5 Multimode Free Space, MM Fiber
IO Matchbox 808nm Laser 808L-1XA LD Module 0.110 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
808L-3XA LD Module 1.6, 3.0 Multimode Free Space, MM Fiber
830L-1XA: 830nm Laser (Diode; MATCHBOX 2) 830L-1XA LD Module 0.070, 0.090, 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
830L-1XA: 830nm Laser (Diode; MATCHBOX 2) 830L-3XA LD Module 1.0 Multimode MM Fiber
850L-1XA: 850nm Laser (Diode; MATCHBOX 2) 850L-1XA LD Module 0.070, 0.110, 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
915L-1XA: 915nm Laser (Diode; MATCHBOX 2) 915L-1XA LD Module 0.080, 0.140, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
975L-1XA: 975nm Laser (Diode; MATCHBOX 2) 975L-1XA LD Module 0.100, 0.140, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-1064 LD Module 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-375 LD Module 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-395 LD Module 0.120 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-405 LD Module 0.050, 0.100, 0.180, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-415 LD Module 0.120 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-445 LD Module 0.100, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-450 LD Module 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-458 LD Module 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-473 LD Module 0.100, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-488 LD Module 0.040, 0.050, 0.060, 0.100, 0.150, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-505 LD Module 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-515 LD Module 0.150 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-522 LD Module 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-633 LD Module 0.100 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-638 LD Module 0.100, 0.150, 0.180 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-642 LD Module 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-647 LD Module 0.140 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-660 LD Module 0.100 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-730 LD Module 0.040 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-785 LD Module 0.100, 0.250, 0.350 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-785S LD Module 0.150, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LBX-980 LD Module 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-532 CW DPSS Lasers 0.050, 0.100, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-553 CW DPSS Lasers 0.050, 0.100, 0.150, 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-561 CW DPSS Lasers 0.050, 0.100, 0.150, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-532 CW DPSS Lasers 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-532S CW DPSS Lasers 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-553 CW DPSS Lasers 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-553S CW DPSS Lasers 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-561 CW DPSS Lasers 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-561S CW DPSS Lasers 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-607 LD Module 0.100, 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-640 CW DPSS Lasers 0.300, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LXCc Combiners: Multi-Wavelength Combiners LXCc Combiner Combiners 0.100, 0.200, 0.300, 0.400, 0.500 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
MatchBox Combiner MatchBox Combiner Combiners 0.050, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
RHAML-E RHAML-XXXX-YY-Z-E LD Module, Line Modules 0.100 Single-Mode Lasers Free Space, Line
RHAML-XXXX-YY-Z LD Module, Line Modules 0.100 Single-Mode Lasers Free Space, Line
RML126FC RML126FC LD Module 0.100 Single-Mode Lasers SM Fiber
RML150FC RML150FC LD Module 0.080 Single-Mode Lasers SM Fiber
RML2040-XXXX-YY-ZZ LD Module, Line Modules 2.0 Single-Mode Lasers Free Space, Line
RML2240 LD Module 1.5 Single-Mode Lasers, Multimode MM Fiber, SM Fiber
RML2540-XXXX-YY-ZZ LD Module, Line Modules 1.0, 2.0 Single-Mode Lasers, Multimode Free Space, Line
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Matchbox Series

R1Z4-Matchbox Laser

The Matchbox series offers excellent performance and reliability in an ultra-compact “all-in-one” integrated laser head.  They come standard with an integrated internal voltage up-conversion that allows using a 5V power supply while maintaining low noise operation. The monolithic design of the Matchbox Series laser includes thermally stabilized optics in a hermetically sealed housing, ensuring reliable and maintenance-free operation.  All the Matchbox series modules include a 12-month warranty and are RoHS compliant.  All of these features make them the ideal laser source for integration into commercial flow cytometers.

LaserBoxx Low Noise Series

The LaserBoxx low noise Series is a CW diode laser module in a variety of diode wavelengths from 375 to 785nm, with output powers up to 350mW. This compact, self-contained laser module is available in turn-key or OEM versions and utilizes a proprietary alignment-free, monolithic resonator, and comes standard with a graphic user interface with remote diagnostics via USB, RS232, or direct I/O interface.

LXCc Series

R2Z3-L4Cc Combiner

The LXCc series is the most compact and flexible all-in-one multicolor laser combiner, with up to 7 laser lines, and up to 500mW output power per line. The turnkey or OEM versions allow a large choice of lasers from 375nm up to 1064nm. The extension module provides the ultimate level of flexibility with up to 4 optical fiber outputs, integrated fast switching output ports for FRAP, or adjustable split power for light-sheet microscopy.

RHAML Series

The RHAML series of diode laser modules deliver a uniform, stable output beam that crucual for machine vision applcations, especially in 3D vision systems. The compact, RHAML series is a reliable light source that incoroporates a fucusing lens that can be easily adjusted by the user. Additionally, the RHAML series is fully IP67 compliant, making it an ideal solution for use in harsh environmental conditions and production/industrial facilities.

RML Series

The RML series of laser diode modules are available with single mode fiber outputs with a set wavelength from 405nm – 2500nm. The compact RML series is available with up to 80mW of output power in a package measuring 15mm in diameter and 40mm in length (without connector) . As an option these modules are offered with a potentiometer for power adjustment, external TTL modulation up to 1MHz and analog modulation up to 100kHz.