Confocal Fluorescence Microscopy Lasers

Confocal microscopy is an optical technique that allows for extremely high spatial resolution imaging by placing two conjunct pinholes in the optical path.  This provides for z-axis resolution as fine as 1 micron, making it possible to measure 3D depth profiles of materials.  In confocal fluorescence microscopy,  a laser is focused through the first pinhole and used to excite the sample, and then the emitted light is collected and focused through the second pinhole to the detector.  Most of the visible wavelengths can be used in confocal fluorescence microscopy, but it’s essential that all confocal fluorescence microscopy lasers have a high quality TEM00 beam profile.  On this page, you will find a list of all of the full range of lasers used for this application, including our multi-laser combiners.

Confocal Microscopy Laser Source Requirements:

•  Wavelengths: Most popular are 405nm, 488nm, 532nm/561nm, and 638nm. Others are often used as well. Wavelength combiners are ideal to cover all wavelengths.

•  Output power: 50 – 500mW with good stability

•  Beam Requirements: TEM00 & low noise. Usually 1x PM fiber-coupled.

RPMC has years of experience supporting Confocal Fluorescence Microscopy applications, helping industry professionals select the right tool for the job.



Let Us Help

In conclusion, if you have any questions or would like some assistance please contact us here. Furthermore, you can email us at info@rpmclasers.com to talk to a knowledgeable Product Manager. Alternatively, use the filters on this page to assist in narrowing down the selection of confocal fluorescence microscopy lasers for sale. Finally, head to our Knowledge Center with our Lasers 101 page and Blogs, Whitepapers, and FAQ pages for further, in-depth reading.

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Type

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Wavelength Selection

Mode

Output

Linewidth

Series

Picture Part Number Type Wavelength (nm) Output power (W) Mode Output Linewidth
1030L-1XB: 1030nm Laser (DPSS; MATCHBOX 2) 1030L-1XB CW DPSS Lasers 1030 0.300, 0.400, 0.500 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port
1123L-1XB: 1123nm Laser (DPSS; MATCHBOX 2) 1123L-1XB CW DPSS Lasers 1123 0.100, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
1319L-1XB: 1319nm Laser (DPSS; MATCHBOX 2) 1319L-1XB CW DPSS Lasers 1319 0.100, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
1550L-1XA LD Module 1550 0.080, 0.120 Single-Mode Lasers Free Space, SM Fiber, PM Fiber
405L-1XA: 405nm Laser (Diode; MATCHBOX 2) 405L-1XA LD Module 405 0.100, 0.150, 0.180 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
450L-3XA: 450nm Laser (HP MM Diode; MATCHBOX 2) 450L-1XA LD Module 450 0.035, 0.050, 0.060 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
488L-1XA: 488nm Laser (Diode; MATCHBOX 2) 488L-1XA LD Module 488 0.020, 0.030, 0.040 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
IO Matchbox 505nm Laser 505L-1XA LD Module 505 0.060 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
515L-1XA LD Module 515 0.010, 0.020, 0.025 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
520L-1XA: 520nm Laser (Diode; MATCHBOX 2) 520L-1XA LD Module 520 0.040, 0.070, 0.080 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
532L-1XB: 532nm Laser (DPSS; MATCHBOX 2) 532L-1XB CW DPSS Lasers 532 0.100, 0.150, 0.160, 0.200 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port
532L-2XB: 532nm Laser (SLM DPSS; MATCHBOX 2) 532L-2XB CW DPSS Lasers 532 0.025, 0.040, 0.050 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
532L-3XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-3XB CW DPSS Lasers 532 0.400, 0.500 Multimode Free Space, MM Fiber, SMA Port
532L-4XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-4XB CW DPSS Lasers 532 0.050, 0.080, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
532L-4XB: 532nm Laser (HP DPSS; MATCHBOX 2) 532L-6XB CW DPSS Lasers 532 0.050, 0.080, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber, SMA Port Narrow
638L-1XA: 638nm Laser (Diode; MATCHBOX 2) 638L-1XA LD Module 638 0.060, 0.080, 0.100, 0.120, 0.170, 0.500, 0.600 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
638L-1XA: 638nm Laser (Diode; MATCHBOX 2) 638L-3XA LD Module 638 0.500, 0.600 Multimode Free Space, MM Fiber
660L-1XA: 660nm Laser (Diode; MATCHBOX 2) 660L-1XA LD Module 660 0.060, 0.080, 0.090, 0.110 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
785L-1XA: 785nm Laser (Diode; MATCHBOX 2) 785L-1XA LD Module 785 0.120, 0.150, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
785L-3XA: 785nm Laser (HP Diode; MATCHBOX 2) 785L-3XA LD Module 785 1.5 Multimode Free Space, MM Fiber
IO Matchbox 808nm Laser 808L-1XA LD Module 808 0.110 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
808L-3XA LD Module 808 1.6, 3.0 Multimode Free Space, MM Fiber
830L-1XA: 830nm Laser (Diode; MATCHBOX 2) 830L-1XA LD Module 830 0.070, 0.090, 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
830L-1XA: 830nm Laser (Diode; MATCHBOX 2) 830L-3XA LD Module 808 1.0 Multimode MM Fiber
850L-1XA: 850nm Laser (Diode; MATCHBOX 2) 850L-1XA LD Module 850 0.070, 0.110, 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
915L-1XA: 915nm Laser (Diode; MATCHBOX 2) 915L-1XA LD Module 915 0.080, 0.140, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
975L-1XA: 975nm Laser (Diode; MATCHBOX 2) 975L-1XA LD Module 975 0.100, 0.140, 0.170 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
He-Ne Power Supplies HeNe Lasers 0.002 Single-Mode Lasers Free Space
Image Laser Diodes TO-Can Packages HL405 Single Emitter 405 0.300, 0.600, 1.0, 3.5 Single-Mode Lasers, Multimode Free Space
Image Laser Diodes TO-Can Packages HL649 Single Emitter 649 0.150 Single-Mode Lasers Free Space
LBX-1064 LD Module 1064 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-375 LD Module 375 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-395 LD Module 375 0.120 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-405 LD Module 405 0.050, 0.100, 0.180, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-415 LD Module 415 0.120 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-445 LD Module 445 0.100, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-450 LD Module 450 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-458 LD Module 457.9 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-473 LD Module 473 0.100, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-488 LD Module 488 0.040, 0.050, 0.060, 0.100, 0.150, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-505 LD Module 505 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-515 LD Module 515 0.150 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-522 LD Module 522 0.070 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-633 LD Module 633 0.100 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-638 LD Module 638 0.100, 0.150, 0.180 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-642 LD Module 642 0.130 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-647 LD Module 647 0.140 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-660 LD Module 660 0.100 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-730 LD Module 730 0.040 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-785 LD Module 785 0.100, 0.250, 0.350 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LBX-785S LD Module 785 0.150, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LBX-980 LD Module 980 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-532 CW DPSS Lasers 532 0.050, 0.100, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-553 CW DPSS Lasers 553 0.050, 0.100, 0.150, 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LCX-561 CW DPSS Lasers 561 0.050, 0.100, 0.150, 0.200, 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LGK 7512 HeNe Lasers 594 0.002 Single-Mode Lasers Free Space
LGK 7608 HeNe Lasers 633 0.002 Single-Mode Lasers Free Space
LGK 7610 HeNe Lasers 633 0.002 Single-Mode Lasers Free Space
LGK 7621 HeNe Lasers 633 0.005 Multimode Free Space
LGK 7627 HeNe Lasers 633 0.005, 0.010 Single-Mode Lasers, Multimode Free Space
LGK 7628 HeNe Lasers 633 0.005, 0.007 Single-Mode Lasers Free Space
LGK 7634 HeNe Lasers 633 0.002, 0.003 Single-Mode Lasers Free Space
LGK 7650 HeNe Lasers 633 0.0005, 0.001 Single-Mode Lasers Free Space
LGK 7653 HeNe Lasers 633 0.010 Single-Mode Lasers Free Space
LGK 7654 HeNe Lasers 633 0.010 Single-Mode Lasers Free Space
LGK 7655 HeNe Lasers 633 0.0006, 0.001 Single-Mode Lasers Free Space
LGK 7665 HeNe Lasers 633 0.015, 0.018, 0.020 Single-Mode Lasers Free Space
LGK 7672 HeNe Lasers 633 0.002 Single-Mode Lasers Free Space
LGK 7785 HeNe Lasers 543 0.001, 0.002 Single-Mode Lasers Free Space
LGK 7786 HeNe Lasers 543 0.0005, 0.0007, 0.001, 0.0015 Single-Mode Lasers Free Space
LGR 7608 HeNe Lasers 633 0.0015 Single-Mode Lasers Free Space
LGR 7610 HeNe Lasers 633 0.002 Single-Mode Lasers Free Space
LGR 7621 HeNe Lasers 633 0.002, 0.005 Single-Mode Lasers, Multimode Free Space
LGR 7627 HeNe Lasers 633 0.005, 0.010 Single-Mode Lasers Free Space
LGR 7628 HeNe Lasers 633 0.005 Single-Mode Lasers Free Space
LGR 7634 HeNe Lasers 633 0.002 Single-Mode Lasers Free Space
LGR 7650 HeNe Lasers 633 0.005 Single-Mode Lasers Free Space
LGR 7655 HeNe Lasers 633 0.001 Single-Mode Lasers Free Space
LGR 7656 HeNe Lasers 633 0.0005 Single-Mode Lasers Free Space
LGR 7660 HeNe Lasers 633 0.001 Single-Mode Lasers Free Space
LGR 7695 HeNe Lasers 633 0.0007 Single-Mode Lasers Free Space
LPX-532 CW DPSS Lasers 532 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-532S CW DPSS Lasers 532 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-553 CW DPSS Lasers 553 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-553S CW DPSS Lasers 553 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-561 CW DPSS Lasers 561 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-561S CW DPSS Lasers 561 0.300 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber Narrow
LPX-607 LD Module 607 0.100, 0.200 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LPX-640 CW DPSS Lasers 640 0.300, 0.500 Single-Mode Lasers Free Space, MM Fiber, SM Fiber, PM Fiber
LXCc Combiners: Multi-Wavelength Combiners LXCc Combiner Combiners Multiple Wavelength Options 0.100, 0.200, 0.300, 0.400, 0.500 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
MatchBox Combiner MatchBox Combiner Combiners Multiple Wavelength Options 0.050, 0.100 Single-Mode Lasers, Multimode Free Space, MM Fiber, SM Fiber, PM Fiber
R Series R0633 LD Module, Single Emitter, Volume Bragg Grating (VBG) 633 0.020, 0.050 Single-Mode Lasers Free Space, PM Fiber Narrow
R Series R0638 LD Module, Single Emitter, Volume Bragg Grating (VBG) 638 0.025, 0.060, 0.300 Single-Mode Lasers, Multimode Free Space, MM Fiber, PM Fiber Narrow
R Series R0660 LD Module, Single Emitter, Volume Bragg Grating (VBG) 660 0.060 Single-Mode Lasers, Multimode Free Space Narrow
R Series R0680 LD Module, Single Emitter, Volume Bragg Grating (VBG) 680 0.300 Single-Mode Lasers, Multimode Free Space, MM Fiber Narrow
R Series R0780 LD Module, Single Emitter, Volume Bragg Grating (VBG) 780 0.050, 0.100 Single-Mode Lasers, Multimode Free Space, PM Fiber Narrow
R Series R0783 LD Module, Single Emitter, Volume Bragg Grating (VBG) 783 0.050, 0.100 Single-Mode Lasers, Multimode Free Space, SM Fiber, PM Fiber Narrow
R Series R0785 LD Module, Single Emitter, Volume Bragg Grating (VBG) 785 0.050, 0.100, 0.200, 0.350, 0.600 Single-Mode Lasers, Multimode Free Space, MM Fiber, PM Fiber Narrow
R Series R0808 LD Module, Single Emitter, Volume Bragg Grating (VBG) 808 0.050, 0.100, 0.200, 0.350, 0.600 Single-Mode Lasers, Multimode Free Space, MM Fiber, PM Fiber Narrow
R Series R0830 LD Module, Single Emitter, Volume Bragg Grating (VBG) 830 0.100, 0.200, 0.350, 0.600 Single-Mode Lasers, Multimode Free Space, MM Fiber, PM Fiber Narrow
R Series R0976 LD Module, Single Emitter, Volume Bragg Grating (VBG) 976 0.220, 0.500, 0.750, 4.0, 5.0 Single-Mode Lasers, Multimode Free Space, MM Fiber Narrow
R Series R1030 LD Module, Single Emitter, Volume Bragg Grating (VBG) 1030 0.100, 0.280, 0.450 Single-Mode Lasers, Multimode Free Space, SM Fiber, PM Fiber Narrow
R Series R1053 LD Module, Single Emitter, Volume Bragg Grating (VBG) 1053 0.050, 0.120, 0.200, 0.300, 0.500 Single-Mode Lasers, Multimode Free Space, SM Fiber, PM Fiber Narrow
R Series R1064 LD Module, Single Emitter, Volume Bragg Grating (VBG) 1064 0.050, 0.150, 0.300, 0.350, 0.600 Single-Mode Lasers, Multimode Free Space, MM Fiber, PM Fiber Narrow
R1064.X Single Emitter, Volume Bragg Grating (VBG) 1064 0.050, 0.120, 0.300 Single-Mode Lasers Free Space, SM Fiber, PM Fiber Narrow

Matchbox Series

R1Z4-Matchbox Laser

The Matchbox series offers excellent performance and reliability in an ultra-compact “all-in-one” integrated laser head.  They come standard with an integrated internal voltage up-conversion that allows using a 5V power supply while maintaining low noise operation. The monolithic design of the Matchbox Series laser includes thermally stabilized optics in a hermetically sealed housing, ensuring reliable and maintenance-free operation.  All the Matchbox series modules include a 12-month warranty and are RoHS compliant.  All of these features make them the ideal laser source for integration into commercial flow cytometers.

LGK Series

The LGK Series of Gas Lasers include a wide range of HeNe and Argon lasers with wavelengths at 488nm, 515nm, 543nm, 594nm, and 633nm.

HL Series

TG420

The HL Series of laser diodes are available in a wide range of wavelengths from violet to red and infrared in support of a broad range of applications. These applications include display, medical, biosciences, industrial tools (sensor, leveler), machine vision, scanners, printers and a myriad of other applications being developed in the industry.

LaserBoxx Low Noise Series

The LaserBoxx low noise Series is a CW diode laser module in a variety of diode wavelengths from 375 to 785nm, with output powers up to 350mW. This compact, self-contained laser module is available in turn-key or OEM versions and utilizes a proprietary alignment-free, monolithic resonator, and comes standard with a graphic user interface with remote diagnostics via USB, RS232, or direct I/O interface.

LGR Series

The LGR Series of Helium-Neon replacement tubes include different output powers, polarizations, and beam sizes.

LXCc Series

R2Z3-L4Cc Combiner

The LXCc series is the most compact and flexible all-in-one multicolor laser combiner, with up to 7 laser lines, and up to 500mW output power per line. The turnkey or OEM versions allow a large choice of lasers from 375nm up to 1064nm. The extension module provides the ultimate level of flexibility with up to 4 optical fiber outputs, integrated fast switching output ports for FRAP, or adjustable split power for light-sheet microscopy.

R Series

R Series

The R series of wavelength stabilized single mode and multimode laser diodes offer narrow wavelength spectrum in wavelengths from 633nm thru 1064nm. Package options range from components as basic as a TO-56 or 14-pin BF packaged diodes, to OEM modules including electronics, to UL/CE and IEC certified turn-key systems.